Danae Schulz

Schulz Danae-01_decrease_sizeAssistant Professor of Biology

F.W. Olin Science Center, Room 2351
1250 N. Dartmouth Ave.
Claremont, CA 91711
909.621.8767
dschulz@hmc.edu

Education and Professional Experience

  • B.A., Biology, Tufts University
  • B.M., Violin performance, New England Conservatory
  • PhD, Molecular and Cell Biology, University of California Berkeley
  • Postdoctoral Research Fellow, Rockefeller University
  • Visiting Assistant Professor, Bard College

Teaching

  • Bio 111: Molecular Biology Lab (Fall)
  • Bio 189: Topics in Biochemistry and Molecular Biology (Fall)
  • Bio 160: Molecular Immunology (Spring)
  • Bio 52: Introduction to Biology (Spring)
  • Bio 23: Biology Laboratory (Spring)

Research Interests

Danae studies the African trypanosome, a protozoan parasite that causes sleeping sickness in humans and nagana in cattle. Trypanosomes are transmitted to the bloodstream of a mammal through the bite of a tsetse fly, eventually leading to coma and death. Danae would like to understand what allows trypanosomes to reprogram themselves to adapt as they move between the differing environments of the fly midgut and the mammalian bloodstream, with an eye toward trying to manipulate these adaptations to generate new therapies. See also, Lab web page.

Website

Lab web page.

Selected Publications

Parasite Papers

Schulz, D. Mugnier, MR, Boothroyd, CE, Papavasiliou, FN. 2016. Detection of Variant Surface Glycoprotein switching by magnetic activated cell sorting and flow cytometry. Journal of Visual Experiments, Oct 19;(116). doi: 10.3791/54715

Schulz, D. Papavasiliou, F.N. 2016. The VEXing problem of monoallelic expression in the African trypanosome. Proc Natl Acad Sci U S A. Jun 17. pii: 201608546. [article]

Mugnier, MR, Papavasiliou, FN, Schulz, D. 2016. Vesicles as Vehicles for Virulence. Trends Parasitol. 2016 Jun;32(6):435-6. doi: 10.1016 [article]

Schulz, D, Papavasiliou, FN, Kim, HS. 2016. Base J and H3.V regulate transcriptional termination in Trypanosoma brucei. PLoS Genet 12(1): e1005762 [article]

Schulz D, Mugnier MR, Paulsen E-M, Kim H-S, Chung C-wW, Tough DF et al. 2015. Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome. PLoS Biol 13(12): e1002316. [article]

Hovel-Miner G, Mugnier M, Papavasiliou FN, Pinger J, Schulz D. 2015. Springer, Results Probl Cell Differ. 57:23-46. A host-pathogen interaction reduced to first principles: antigenic variation in Trypanosoma brucei. Springer, Results Probl Cell Differ. 57:23-46.  [article]

Immunology Papers

Schulz, D, Vassen, L, Chow, K, Amin, RA, Moroy, T, Schlissel, MS. Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1. 2012. Journal of Experimental Medicine, Jan 16;209(1):187-99.pdf

Chow, KT, Schulz, D, McWhirter, SM, Schlissel, MS. Gfi1 and Gfi1b repress Rag transcription in plasmacytoid dendritic cells in vitro. 2013. PLOS One. Sep24;8(9)e75891.pdf 

Schlissel, MS, Schulz, D, Vettermann, CA. Histone Code for Regulating V(D)J recombination. 2009. Molecular Cell, Jun 26;34(6):639-40.  pdf

Curry, JD, Schulz, D, Guidos, CJ, Danska JS, Nutter, L, Nussenzweig A, Schlissel MS. Chromosomal reinsertion of broken RSS ends during T cell development. 2007. J Ex Med, 204(10):2293-303 pdf

Degner SC, Verma-Gaur J, Wong TP, Bossen C, Iverson GM, Torkamani A, Vettermann C, Lin YC, Ju Z, Schulz D, et al. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. 2011.Proceedings of the National Academy of Sciences, Jun 7;108(23):9566-71 pdf