Danae Schulz, PhD, studies the African trypanosome, a protozoan parasite that causes sleeping sickness in humans and nagana in cattle. Trypanosomes are transmitted to the bloodstream of a mammal through the bite of a tsetse fly, eventually leading to coma and death. She would like to understand what allows trypanosomes to reprogram themselves to adapt as they move between the differing environments of the fly midgut and the mammalian bloodstream, with an eye toward trying to manipulate these adaptations to generate new therapies.
- hmc.edu 12/15/16 New Technique Helps Indentify Parasite “Switchers”
- Science Daily 12/8/15 African sleeping sickness: study suggests new way to help the immune system fight off parasite
- PLOS Biology 12/8/15 Bromodomain Proteins Contribute to Maintenance of Bloodstream Form State Identity in the African Trypanosome