Predicting Antibody Developability From Sequence Using Machine LearningJanuary 1, 2020
Dassault Systèmes BIOVIA Computer Science/Biology, 2019-20
Liaison(s): Ian Kerman and Dr. Reza Sadeghi
Advisor(s): Jessica Wu and Naim Matasci
Students(s): Emily Zhao (PM-F), Tom Dougherty (PM-S), Xingyao Chen, Rachel Schibler, Chan Hong
Antibodies have become prominent therapeutic agents but are costly to develop. Existing approaches to predict developability depend on structure, which requires extensive laboratory or computational work to obtain. To address this issue, we developed a machine learning model to predict developability from sequence alone by extracting physicochemical and learned embedding features. Our model achieves high sensitivity and specificity on a dataset of 2,400 antibodies. These results suggest that sequence is predictive of developability, enabling more efficient development of antibodies.