Network Analysis and Methodology Development for Drug Discovery in Alzheimer’s Disease

Dart NeuroScience, LLC Biology/Computer Science/Mathematics, 2017-18

Liaison(s): Philip Cheung ’96, Qingying Meng, Douglas Fenger
Advisor(s): Eliot Bush
Students(s): Annalise Schweickart, Chloe Chan, Sasha Friedrich, Brendan Murran

The goal of this project, sponsored by Dart Neuro-Science, is to generate potential drug targets relating to memory and neural plasticity, focusing specifically on Alzheimer’s disease. We have developed a novel methodology built on existing network analysis algorithms to identify key genes implicated in Alzheimer’s Disease. This methodology can be used to identify potential drug targets for Alzheimer’s, and in the future might also be used towards drug discovery for other diseases.