{"id":3766,"date":"2018-09-25T00:00:00","date_gmt":"2018-09-25T00:00:00","guid":{"rendered":"https:\/\/wpdev.hmc.edu\/physics\/2018\/09\/25\/computational-lenses-with-x-rays-and-electrons\/"},"modified":"2018-09-25T00:00:00","modified_gmt":"2018-09-25T00:00:00","slug":"computational-lenses-with-x-rays-and-electrons","status":"publish","type":"physics_colloquium","link":"https:\/\/www.hmc.edu\/physics\/research\/colloquium\/computational-lenses-with-x-rays-and-electrons\/","title":{"rendered":"Computational lenses with x-rays and electrons"},"content":{"rendered":"<figure id=\"page-featured-image\" class=\"wp-block-image is-style-alignleft\" data-pic=\"pic-619.jpg\"><img decoding=\"async\" src=\"https:\/\/www.hmc.edu\/physics\/wp-content\/uploads\/sites\/22\/2023\/01\/pic-619.jpg\" alt=\"Promotional image for talk: Elements of a successful scientific talk\" data-pic=\"pic-619.jpg\" \/><\/figure>\n<p><strong>Speaker(s):<\/strong> Duane Loh &#8217;04<\/p>\n<p>Computational lenses replace the role of physical lenses in an imaging instrument with&nbsp;their computational equivalent. An example of this is&nbsp;three-dimensional&nbsp;single particle imaging. Here,&nbsp;the computational lenses classify an unsorted ensemble of&nbsp;measurements to form the most compatible three-dimensional&nbsp;structure from lower-dimensional projections. Specifically, many random and noisy two-dimensional diffraction&nbsp;patterns&nbsp;of individual biomolecules are recorded at high speed. Thereafter, a Bayesian&nbsp;classification algorithm infers the most likely&nbsp;family of three-dimensional structures that&nbsp;is compatible with these measurements.<\/p>\n<p> In many applications of computational lenses, the basic principles behind either the image&nbsp;formation process or the&nbsp;sample-probe interactions have been known for many decades.&nbsp;However, pursuing their consequences are numerically&nbsp;intensive and requires high-fidelity&nbsp;measurements. In the past two decades, owing to faster computers and brighter X-&nbsp;ray\/electron sources, many of these principles can now be effectively translated and inte-&nbsp;grated directly into imaging&nbsp;instruments as computational lenses.<\/p>\n<p> In this talk, I will outline the basic principles of computational lenses in high resolution X-ray and electron microscopy,&nbsp;show examples of their applications, describe new applications that our group is currently developing, and speculate on&nbsp;the limitations and opportunities in high resolution X-ray and electron microscopy.<\/p>\n","protected":false},"author":1,"featured_media":0,"template":"","class_list":["post-3766","physics_colloquium","type-physics_colloquium","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hmc.edu\/physics\/wp-json\/wp\/v2\/physics_colloquium\/3766","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hmc.edu\/physics\/wp-json\/wp\/v2\/physics_colloquium"}],"about":[{"href":"https:\/\/www.hmc.edu\/physics\/wp-json\/wp\/v2\/types\/physics_colloquium"}],"author":[{"embeddable":true,"href":"https:\/\/www.hmc.edu\/physics\/wp-json\/wp\/v2\/users\/1"}],"wp:attachment":[{"href":"https:\/\/www.hmc.edu\/physics\/wp-json\/wp\/v2\/media?parent=3766"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}