Assistant Professor of Biology F. W. Olin Science Center, Room 2364 1250 N. Dartmouth Ave. Claremont, CA 91711 (909) 607-1141 Daniel_Stoebel@hmc.edu

Education & Professional Experience

• B.A., Biology, Pomona College
• Ph.D., Ecology and Evolution, Stony Brook University
• Postdoctoral Research Fellow, Trinity College, University of Dublin
• Postdoctoral Research Fellow, University of Houston
• Assistant Professor of Biology, Harvey Mudd College

Teaching

• Bio 113: Molecular Biology
• Bio 52: Introduction to Biology
• Bio 164: Genetics
• Biology 54: Introductory Biology Lab
• Writing 1: Introduction to Academic Writing

Research Interests

Work in the Stoebel Lab focuses on the molecular biology and evolution of bacterial regulatory networks. The E. coli global transcriptional regulator RpoS is the focus of work, because it allows for the integration of molecular biology, physiology and evolution. Projects include documenting naturally ocuring variation in RpoS levels, exploring the physiological consequencs of this variation, measuring the effect of variation on the transcriptome, and determining molecular mechanisms of evolution of the RpoS regulon.

Selected Publications

Y. Wang, C. D. Arenas, D. M. Stoebel, and T. F. Cooper. 2013. Genetic background affects epistatic interactions between two beneficial mutations. Biology Letters doi:10.1098/rsbl.2012.0328. [article]

E. Snyder*, D. M. Gordon, and D. M. Stoebel. 2012. Escherichia coli lacking RpoS are rare in natural populations of non-pathogens. G3: Genes | Genomes | Genetics, 2:1341-4 [article]

Cameron, A. D. S., D. M. Stoebel, and C. J. Dorman. 2011. DNA supercoiling is differentially regulated by environmental factors and FIS in Escherichia coli and Salmonella enterica. Molecular Microbiology, 80:85-101 [article]

Stoebel, D. M. & C. J. Dorman. 2010. The effect of mobile element IS10 on experimental regulatory evolution in Escherichia coli. Molecular Biology and Evolution, 27: 2105-2112. [article]

Stoebel, D. M. & D. E. Dykhuizen. 2010. Waste and yet want not. Molecular Cell, 38:625-626. [article]

Stoebel, D. M., K. Hokamp, M. S. Last & C. J. Dorman. 2009. Compensatory evolution of gene regulation in response to stress by E. coli lacking RpoS. PLoS Genetics, 5: e1000671  [article]

Stoebel, D. M., A. Free & C. J. Dorman. 2008. Anti-silencing: overcoming H-NS-mediated repression of transcription in Gram-negative enteric bacteria. Microbiology, 154: 2533-2545. [article]

Stoebel, D. M., A. M. Dean & D. E. Dykhuizen. 2008. The cost of expression of Escherichia coli lac operon proteins is in the process, not in the products.  Genetics, 178:1653-1660. [article]

Stoebel, D. M. 2005. Lack of evidence for horizontal transfer of the lac operon into Escherichia coli. Molecular Biology and Evolution, 22:683-690. [article]

Feldgarden, M., D. M. Stoebel, D. Brisson & D.E. Dykhuizen. 2003. Size doesn't matter: microbial selection experiments address ecological questions. Ecology, 84:1679-1687. [article]